Khat effect on the conduction velocity of nerve fibers in Toad

Dr. Amin A. Thabet

الملخص

Conduction velocity of sciatic of sciatic nerve of toad Buformelano stiticuts was studied by khat extract. Experiments were done by determining the dose dependent of khat using on nerve fiber and as believed khat like amphetamine can relive pain as same as ibuprofen1 has psycho stimulant mediated by dopamine so the groups of experiment that was studied the conduction velocity of the sciatic nerve after pretreatment by khat, then was determined the affected nerve by khat after treatment with haloperidol which known as a dopaminergic blocker. Results were demonstrated that after khat treatment there was a decrease in latent period decrease in the time taken to disseminate excitation through nerve and there was increase in conduction velocity while on the contrary after treatment with haloperidol the latent period and the time taken to propagate provocation along nerve fiber increased with decrease in conduction velocity. accordingly it possibly that khat type of excitant drug , causes increase the conduction velocity of sciatic nerve due to its effects that mediated by dopamine and reverses these effects by haloperidol .